Accordingly, with the extent of PARP cleavage, extensive caspase 3 activation was observed in CML treated by actD and all combinations tested; large caspase 3 activation was monitored also in SAHA treated cells, but only moderate effect was detected when BUT or DAC was used to treat the cells. This evidence concerns the gene CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive.