Since Markowitz et al. [6] discovered mutations in the coding mononucleotide repeats of TGFBR2 in MSI-high colon cancer cells, similar mutations of coding mononucleotide repeats in many other genes (including BAX, MSH3, MSH6, IGF2R and PTEN) have been found in MSI-high colorectal cancers [3], [7], [8], [9]. Here, TGFBR2 is linked to colorectal cancer.