Several previous studies have examined the prognostic role of TGFBR2 or BAX mononucleotide mutations in MSI-high colorectal cancers, yielding inconclusive results due to limited statistical power in most studies [19], [20], [21], [22], [23], [24], [25] (Table 1). The gene discussed is TGFBR2; the disease is colorectal cancer.