At the acute phase of infection and height of viral replication in non-immunized mice the IL-10 to IFNγ ratio was massively favoured towards IL-10, indicating that these host responses were biased towards decreasing inflammation and pathology rather than clearing the virus, which most likely lead to ineffective viral clearance and high virus titers still being detectable at 120 hours p.i. It was interesting to note replication of virus to a much higher titer in spleen of recNP immunized mice compared to liver. This evidence concerns the gene IFNG and infection.