Our results show that Pglyrp1 (and other Pglyrps to a lesser extent) promotes Th1 responses, because Pglyrp1−/− mice (and also Pglyrp2−/− and Pglyrp4−/− mice) have reduced inflammation in oxazolone-induced contact dermatitis. The gene discussed is PGLYRP4; the disease is contact dermatitis.