In our model, however, the main difference at the peak of inflammation between WT and atopic dermatitis-sensitive Pglyrp-deficient mice, which determines the enhanced inflammatory responses and higher IgE production in Pglyrp-deficient mice, is the overactivation of Th17 cells and reduced numbers of Treg cells in the atopic dermatitis-sensitive mice. The gene discussed is PGLYRP1; the disease is atopic eczema.