Because WT mice were able to limit skin inflammation in the atopic dermatitis model more effectively than Pglyrp3−/− and Pglyrp4−/− mice, we then tested whether this difference is due to impaired generation or function of regulatory T cells (CD4+FoxP3+ Treg) in Pglyrp-deficient mice. The gene discussed is PGLYRP1; the disease is atopic eczema.