PGLYRP4 and atopic eczema: Expression of Pglyrp4 mRNA was highly increased in the atopic dermatitis model and was the highest in Pglyrp2−/−Pglyrp3−/− and Pglyrp3−/− mice, suggesting a possibility of compensatory expression of Pglyrp4 in mice deficient in Pglyrp3 or changes in the regulation of transcription or stability of Pglyrp4 mRNA, since Pglyrp3 and Pglyrp4 genes are tightly linked in the psoriasis sensitivity locus on chromosome 3 in mice and their expression is correlated with the expression of keratinocytes differentiation genes [21].