In WT mice Pglyrp3 and Pglyrp4 offer protection in the oxazolone atopic dermatitis model, Pglyrp1 has a pro-inflammatory effect both atopic and contact dermatitis models, and Pglyrp2 has little effect on the atopic dermatitis and has a pro-inflammatory effect in the contact dermatitis model of skin inflammation. The gene discussed is PGLYRP2; the disease is contact dermatitis.