Nevertheless, the findings that KIR2DL1 and not other receptors is the main player determining HLA-Cw6-mediated thresholds on NK cells, and that human NK cell clones vary in their intrinsic activation thresholds, may be important for predicting the outcome of allogeneic haematopoietic stem cell transplantation in treatment of acute myeloid leukemia, where NK cell activation plays a major role [35]. The gene discussed is KIR2DL1; the disease is acute myeloid leukemia.