The aim of our study was to bring a further and more in deep insight into the distribution of the IgE reactivity to three panallergen groups (profilins, PR-10 and tropomyosins) in 3,113 individuals with a history of food allergy, rhinitis, asthma or atopic dermatitis, either looking at the reciprocal IgE positivity of each group compared to the others, or within each of the three panallergen groups. This evidence concerns the gene IGHE and rhinitis.