CCR6 and non-small cell lung carcinoma: Furthermore, inhibition of ERK signaling by PD98059 decreased the potential of CCL20 to induce colony formation while it did not affect the basal numbers of colonies formed, thus demonstrating the pro-proliferative potential of CCL20/CCR6 auto-signaling in NSCLC and marking ERK as an intracellular mediator of these signals.