Our previous study [5] has established that, in contrast to the CTCL cell lines and tissues, native leukemic CTCL cells are quiescent and require both mitogen priming and IL-2 stimulation to activate mTORC1 as well as PI3K/Akt and MEK/ERK signaling pathways. Here, AKT1 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.