It is interesting to note that, excluding the TCF7L2 SNP, three of the four variants most strongly associated with type 2 diabetes in the MAGIC study [1] (MTNR1B rs10830963, PROX1 rs340874 and GCKR rs780094) have odds ratios of less than one in our South Asian populations (Figure 2). The gene discussed is MTNR1B; the disease is type 2 diabetes mellitus.