Recent data indicate that miRNA dysregulation may also contribute to the pathogenesis of multiple sclerosis (MS): Overexpression of miRNAs that target CD47 was found to contribute to macrophage-mediated damage in active MS lesions and miRNA expression profiling in whole blood or leukocytes derived from MS patients suggests an aberrant expression of various miRNAs in the peripheral immune compartment [6], [7]. This evidence concerns the gene CD47 and myeloid sarcoma.