Fig. 5D shows that destabilizing hsp90 by hypericin abrogated hsp90-Hop intermediate complex formations, preventing their co-immunoprecipitation. Furthermore, the hsp90 inactivation and degradation caused dramatic decreases in Hop cellular contents. Similar observations were reported in human colon carcinoma cells in which HOP levels correlated with those of hsp90 [29]. Here, STIP1 is linked to colon carcinoma.