In this regard, it had been described decreased plasma levels of acyl ghrelin IgG autoAbs present as free or total immunoglobulins in patients with anorexia nervosa, suggesting that altered production of ghrelin reactive autoAbs is associated with persistently elevated plasma ghrelin and eventually ghrelin resistance in anorexia nervosa [67]. The gene discussed is GHRL; the disease is anorexia nervosa.