The chronic infusion of urocortin into the arcuate-ventromedial region causes anorexia suggests that both the ventromedial hypothalamic nucleus, which express the CRFR2, and the arcuate nucleus, which express CRFR1, can be sites of the anorectic effects of CRF-related peptides [88]. The gene discussed is CRHR1; the disease is Anorexia.