Several reports have also shown that reduced levels of Sirt1 lead to the upregulation of acetylated-NF-κB (p65), resulting in an increase in inflammation in the adipose tissue of high-fat diet-induced obese mice [25] or the monocytes of patients with chronic obstructive pulmonary disease (COPD) related to smoking [26]. The gene discussed is SIRT1; the disease is chronic obstructive pulmonary disease.