PML and infection: Using a series of cell lines expressing individual EYFP-linked PML isoforms in normal or PML-depleted backgrounds [46], we found that the SUMO-modified forms of all PML isoforms were degraded in an ICP0- and proteasome-dependent manner during infection, consistent with previous studies analysing ICP0’s ability to induce the degradation of endogenous PML during infection [9]–[11].