Although any functional role for the ESSRA-C11orf20 fusion remains to be established, fusions to other nuclear hormone receptor transcription factors have been found in other cancers, including PAX8–PPARG in follicular thyroid tumors [28], EWSR1-NR4A3 in extraskeletal myxoid chondrosarcomas [29], and PML-RARA in acute promyelocytic leukemia [30]. The gene discussed is NR4A3; the disease is acute promyelocytic leukemia.