Indeed, although none were found to be recurrent, 4 of the 11 gene fusions identified in a previous UHTS survey of RNA from a series of melanomas were strikingly similar to the ESRRA-C11orf20 fusion; adjacent genes in the same transcriptional orientation were rearranged to yield a fusion transcript in which the order of the two participating genes was reversed [10]. This evidence concerns the gene ESRRA and melanoma.