The predicted drENOSF1β has all the key features of the human cancer-associated gene as well as a bacterial gene with a known function: drENOSF1β and hsENOSF1β are both close homologues (slightly > 50% sequence identity) to the bacterial protein fuconate dehydratase (FucD) and share the conserved residues needed for that enzyme's catalytic activity (Figure 2B) [4,7,12]. This evidence concerns the gene ENOSF1 and cancer.