Since the role of CRMP2 phosphorylation has not been previously examined in the adult neurogenic niche, or in HIV-associated neurodegenerative disorders (HAND), we sought to better understand the potential function of this protein in the molecular mechanisms involved in CDK5-mediated dysregulation of adult neurogenesis using an in vitro model of CDK5 activation in adult hippocampal NPCs [17], and in vivo in the brains of patients with HIV and in an animal model of HIV protein neurotoxicity. This evidence concerns the gene DPYSL2 and HIV-associated neurocognitive disorder.