Concentrations of Th1 cytokines were differentially expressed; IFN-γ mRNA were increased for the CTC+CR treatment at the peak (i.e. day 8 p.i.)and late (i.e. day 14 p.i.)stages of infection, whereas IL-2 mRNA was increased at clearance (i.e. day 21 p.i.), and TNF-α mRNA was increased at the peak stage and decreased at the late stage of infection in mice administered CTC. The gene discussed is TNF; the disease is infection.