Solomon et al [19] reported that neoplasms with both cytoplasmic and nuclear maspin expression had lower VEGF and cyclooxygenase-2 (COX-2) expression than neoplasms with cytoplasmic maspin expression only, so suppression of VEGF by maspin may thus occur through a COX-2 mediated pathway. The gene discussed is SERPINB5; the disease is neoplasm.