Malignant pleomorphic adenoma possessed the highest value of maspin expression and low MCM2 expression, this is in accordance with Umekita et al [44] who observed that high maspin expression in breast carcinoma was associated with poor prognosis, and this was explained by genetic alteration at the maspin gene locus contributing to the loss of tumor suppressing function of the maspin protein. The gene discussed is SERPINB5; the disease is breast carcinoma.