In addition, a very recent report by Kryczek et al. [110] showed for the first time an IL-17+ regulatory T cells expressing FoxP3 (IL-17+Foxp3+CD4+ T cells) in the tumor microenvironment of inflammatory tumors such as colon cancer as well as chronic inflammation tissue of the colon but not in renal cell carcinoma, melanoma or ovarian carcinomas. The gene discussed is FOXP3; the disease is hereditary clear cell renal cell carcinoma.