In the perspective of the complex interplay between the immune system and tumor microenvironment, TGF-β is an immunosuppressive cytokine that function at several levels in the tumor microenvironment which also encompasses reduction in the amount of antigen presentation by DCs [12-14], reduction in the proliferation of T cells (Th1, Th2 and CTL), suppression of NK cells cytotoxic activity, and stimulation of Treg cells proliferation thus impeding immune surveillance of the developing tumor [91,92]. Here, TGFB1 is linked to neoplasm.