TGFB1 and neoplasm: Conversely, DCs at the tumor microenvironment, which possess an immature phenotype, is not necessarily conducive to the activation of antitumor immune responses due to tumor-derived local immunosuppressive cytokines milieu as transforming growth factor (TGF-β), and IL-10 and growth factors as vascular endothelial growth factor (VEGF) that may instead suppress or re-conditioning DCs function and/or myeloid-derived suppressor cells (MDSCs) [7,9].