In addition, a very recent report by Kryczek et al. [110] showed for the first time an IL-17+ regulatory T cells expressing FoxP3 (IL-17+Foxp3+CD4+ T cells) in the tumor microenvironment of inflammatory tumors such as colon cancer as well as chronic inflammation tissue of the colon but not in renal cell carcinoma, melanoma or ovarian carcinomas. This evidence concerns the gene CD4 and neoplasm.