It is clear that IFN-γ, IL-17 and TGF-β are capable of exerting multiple effects within tumor microenvironment site, many of the exerted effects are contextual hence, compelling further investigations in that regard along with any attempt of their modulation that should be approached with a definite knowledge of the initial level of cytokines and their complex interaction with particular type of tumors and the immune cells. This evidence concerns the gene IFNG and neoplasm.