The latter is supported by the two stage skin carcinogenesis model using 7,12-dimethyl benz(a) anthracene/12-O-tetradecanoylphorbel-13-acetate (TPA)-induced papilloma where the latter upregalated IL-17 expression in the skin papilloma and TH17 in the draining lymph nodes. The gene discussed is IL17A; the disease is papilloma.