TNF and neoplasm: Moreover, a set of key cytokines profile (IL-1β, IL-6, TNF-α, and TGF-β) was detected in ovarian tumor cells, tumor-derived fibroblasts, and APCs, which formed a cytokine milieu that regulated and expanded human IL-17-producing Th17 cells [90] suggesting that these inflammatory cytokines within the tumor microenvironment can provide a favorable niche for developing the unstable Th17 cells and potentially directing them into a dangerous feedback loop.