In this study, we showed that the crown of V3 imposes a strong transcriptional signature pattern on responding CD4 T cells during antigen presentation associated with cell cycle, gene expression, immune response, infection mechanisms, cellular growth, proliferation and antigen presentation Unveiling the key participating molecules in intracellular signaling within the responding CD4 T cells may provide the impetus to design novel therapeutic strategies such as the salvaging of uninfected T cells from HIV-induced AICD. Here, CD4 is linked to infection.