Since we have previously shown that GMME1 inhibits STAT3 phosphorylation in EG7 lymphoma cells, we assessed the level of STAT3 activation first by ELISA at different time points and documented a complete loss of activation following 10 min of GMME1 treatment, an observation that was confirmed by immunoblot (Figure 4D left panels). The gene discussed is STAT3; the disease is lymphoma.