In accordance with previously reported criteria, GISTs can be classified using the following scores: high responders, 0 to <50% residual viable tumor cells with no mitosis, and no obvious Ki-67 immunostaining; moderate responders, >50% to 90% tumor cells, no mitosis, and Ki-67 immunostaining in 0 to <10% of cells; low responders, >50% to 90% tumor cells, mitotic index > 10/50 high-power fields, Ki-67 immunostaining in 20-30% or >30% of cells; and non-responders, >90% tumor cells [17,18]. The gene discussed is MKI67; the disease is neoplasm.