Furthermore, the role of Rac1 in maintaining malignant phenotype of mouse skin tumour cells was investigated and showed that dominant negative Rac1 reduces migration, invasion and tumour growth through inhibition of MAPK signalling [58], while more recently, it was established that FAK signalling is required for TGFbeta-mediated EMT in hepatocytes [21]. This evidence concerns the gene RAC1 and skin neoplasm.