Isoproterenol (ISO) and Ang II-induced cardiac hypertrophy is suppressed in 5-HT2BR-deficient mice, and this effect is accompanied by reduced production of cytokines (IL-6, IL-1β, TGF-β, and TNF-α) and reactive oxygen species in cardiac fibroblasts [82, 83]. Here, TGFB1 is linked to cardiac hypertrophy.