By driving the circuit (Figure 3), TF hypercoagulability is readily involved in an array of metabolic syndromes (e.g., atherosclerosis, hypertension, diabetes II, and obesity) and other clinical manifestations (e.g., cancers, antiphospholipid syndrome (APS), and fetal loss). The gene discussed is TF; the disease is obesity due to melanocortin 4 receptor deficiency.