The combined in vitro and in vivo properties of NE680 and efficacy in imaging LPS/fMLP-induced ALI suggest it may be useful in other chronic neutrophil-driven disease models, such as emphysema/chronic obstructive pulmonary disease, cystic fibrosis, acute neutrophilia, chronic wound healing, rheumatoid arthritis, and infectious diseases. The gene discussed is FPR1; the disease is pulmonary emphysema.