In multivariable logistic regression analyses, independent correlates of HIV diagnosis with CD4 count <200 cells/mm3 were having as a risk for HIV infection not being MSM (OR = 1.99, 95% CI 1.45–2.72), age ≥35 years at diagnosis (OR = 2.14, 95% CI 1.59–2.87), and being of nonwhite race (OR = 1.45, 95% CI 1.05-2.01). This evidence concerns the gene CD4 and HIV infectious disease.