SOD, CAT, GPx, GR, and GST activity were significantly (P < 0.05) diminished in lymphocytes by 44.65%, 54.41%, 64.24%, 50.83%, 50.01%, and 51.12%, 65.85%, 66.63%, 56.47%, 53.55%, respectively, due to VSSA and VRSA infection as compared to control group, which was significantly (P < 0.05) increased by 67.37%, 83.28%, 136.99%, 75.93%, 71.27%, and 79.29%, 129.08%, 184.31%, 94.13%, 86.35% due to treatment of nanoconjugated vancomycin. Here, GSR is linked to infection.