In reports from different research groups, miR-146a and miR155 have been consistently found to be up regulated in synovial fibroblasts (RASFs), PBMCs, synovial fluid, PBMC-derived CD4+ T cells, and Th-17 cells from patients with RA when compared with healthy controls or patients with osteoarthritis (OA) [40, 48–51]. The gene discussed is CD4; the disease is rheumatoid arthritis.