Considering these data as well as the finding that PMNs may degrade HMWK and generate antifungal activity (Figure 1(b)), it is tempting to speculate that during a cutaneous Candida infection, neutrophils, recruited to the site of infection [75, 76], may upon activation release cathepsin G from azurophilic granules, leading to degradation of HMWK, present in blood or connective tissues. The gene discussed is CTSG; the disease is candidiasis.