NME1 and acute myeloid leukemia: Although it might be a useful technique to reduce the serum level of this protein using therapeutic filtration devices such as Hemopurifier that selectively target the removal of immunosuppressive proteins from the entire circulatory system [49], it will be very important to reveal the signal transduction pathways induced by extracellular NM23-H1 protein to increase growth/survival of AML cells.