The individual signaling pathways induced by rNM23-H1 protein were blocked in AML cells using specific pharmacological inhibitors, SB202190 and SKF86002 for p38 MAPK, PD98059 for extracellular signaling kinase (ERK, also known as MEK), and Curcumin for STAT3 [38]. The gene discussed is STAT3; the disease is acute myeloid leukemia.