Concerning the other genes of BCL2 family, studies about the prognostic role of the polymorphism G(-248)A in the promoter region of the BAX gene are contradictive [84, 85], whereas an SNP in the MCL-1 promoter region has been shown to characterize CLL patients at high risk of relapse [86]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.