The antiangiogenic and antitumor efficacy of oltipraz in nude mice was evaluated by measuring its effects on neovascularization in subcutaneous implants seeded with vascular endothelial growth factor and basic fibroblast growth factor-stimulated porcine aortic endothelial cells, and on tumor growth and angiogenesis in SVR murine angiosarcoma xenografts implanted subcutaneously [247]. The gene discussed is VEGFA; the disease is neoplasm.