These proteins dimerize and the resulting ratio of inhibition to activation determines a cell's susceptibility to apoptosis [100]; a higher level of bax expression compared to bcl-2 expression correlates with a better outcome for patients with bladder cancer, and early relapses are more common in patients whose tumors express more bcl-2 than bax (both at the mRNA and protein levels) [105]. This evidence concerns the gene BAX and urinary bladder cancer.