NCOA2 and osteosarcoma: Although GRIP-1/TIF-2 is a coactivator for both GR and TR, a study has shown that GRIP-1/TIF-2 can potentiate GR-mediated transrepression of the collagenase-3 gene in human osteosarcoma cells but has no effect on the transrepression by TR [47] (Figure 2(a)).