It was previously reported that p53 can suppress EZH2 [35], and that E2F can induce EZH2 [36], but little is otherwise known about the direct transcriptional regulation of EZH2. Using ChIP, we determined in 2 prostate cancer cell lines that MYC directly associates with the E-box-containing promoter region of EZH2. While this manuscript was in process, Salvatori et al. reported similar findings in acute myeloid leukemia, showing that Myc directly binds upstream of EZH2 and activates its transcription [29]. The gene discussed is TP53; the disease is prostate cancer.