NFKB1 and esophageal squamous cell carcinoma: Significantly, our data suggest differences in the patterns of NF-κB and Notch1 signaling with respect to lymph node metastasis status in ESCC, demonstrating strong expression of NF-κB in ESCC tissue, but weak expression of Notch1 with lymph node involvement (P < 0.05 for both).