Symptomatic effects of similar extent have been observed with the second-generation MAO-B inhibitor rasagiline (N-Propargyl-1[R]aminoindan), which for example in the TVP-1012 in early monotherapy for PD outpatients (TEMPO) study led to an improvement of about 3 points on the total UPDRS after 3 months at a daily dose of 1 mg per day [5]. Here, MAOB is linked to Parkinson disease.