This trapping of Zn2+ might mimic ZnT3 ablation [41] and indeed, mice with a disruption of the vesicular Zn2+ transporter ZnT3, display complete absence of Zn2+ from synaptic vesicles throughout the brain [42] as well as synaptic and memory deficits comparable to those seen in a cognitively impaired APP transgenic mouse model of AD [41]. Here, APP is linked to Alzheimer disease.