ERBB2 and cancer: When we compared CMTC to 14 published prognostic gene signatures, the highest AUC values were found in the CMTC-3 group in all 248 cancers (0.811) (95% CI = 0.76 to 0.86; P <0.001) and in 111 Her2+/TN tumors (0.718) (95% CI = 0.63 to 0.80; P <0.001).