The top network of molecules generated for budesonide treatment included "cancer", "genetic disorder" and "respiratory disease" and includes proteins such as keratin 6A (KRT6A; P02538), dihydropyrimidinase-like 5 (DPYSL5; Q9BPU6), and interleukin enhancer binding factor 3 (ILF3; Q12906) which had increased expression, while downregulated proteins included cofilin 1(CFL1; P23528), alpha enolase 1(ENO1; P06733) and VIM (Figure 5). The gene discussed is DPYSL5; the disease is respiratory system disorder.