Successive studies demonstrated that the results obtained in experiments with recombinant (r)Dsg1-Ig-His and rDsg3-Ig-His chimeras that led to a conclusion that anti-Dsg 1 and anti-Dsg 3 antibodies are pathogenic in PF and PV, respectively, were complicated by the presence of non-Dsg antibodies [18]. Here, DSG1 is linked to pemphigus foliaceus.