Most of the dysregulated genes have been previously shown to be involved in tumor invasion and metastasis, such as TFPI-2 [17], LOXL2 [22-24], ADAM12m [25,26], IGFBP1 [27,28], integrin α6[29,30], CD44 [31]and CYR61 [32]. This evidence concerns the gene IGFBP1 and neoplasm.