FMR1 and peripheral nerve lesion: While changes in mRNA localization have been observed after pre-conditioning peripheral nerve lesions [26], we found that PNI induces profound changes in activity of kinases associated with translation control (e.g. mTOR and ERK), phosphorylation of their downstream targets and in overall levels of proteins involved in RNA processing and transport (e.g. Mov10, FMRP and rck/p54).