It has been reported that the rates of HBV DNA negative, hepatitis B e antigen (HBeAg) loss and HBeAg seroconversion were 39%, 58% and 48% respectively in the subjects with HBeAg positive chronic hepatitis B (CHB) treated with ADV 10 mg once daily for 5 years, and 66% of them achieved alanine aminotransferase (ALT) normalization and 20% developped HBV mutant [2]. Here, GPT is linked to chronic hepatitis B virus infection.