Although our study is limited by the small samples size, results show that the overall frequency of antigen-specific CD4 and CD8 T-cells that produced IFN-γ in response to MSP142 were low and did not appear to differ according to parasitemia or ages ranging from 0.5 to 5 years and ≥18 years but there was a shift in hierarchy among various T-cell subsets responsive to MSP142 such that the TEM subset was the dominant cell type in adults in contrast to children who had more phenotypically naïve-like, TN cells. This evidence concerns the gene CD4 and parasitic infectious disease.