The overall magnitude of MSP142 driven IFN-γ responses observed for CD4 and CD8 T-cells was generally weaker than that reported for recent studies of regulatory T cell responses in Gambian children with severe and mild malaria [34], [35] and malaria naïve volunteers challenged experimentally a single time with P. falciparum infected erythrocytes [36]. This evidence concerns the gene CD8A and malaria.