IFNG and malaria: Studies of rodent malaria models and limited observations of malaria-naïve humans who became resistant to blood stage P. falciparum challenge after repeated inoculation and drug cure with a small number (∼300) of infected erythrocytes suggest that T-cells and IFN-γ responses, even in the absence of antibodies, confers a degree of protective immunity [6], [7]; however it is unclear whether residual anti-malarial drugs may have contributed to the protection seen [8].