After an adjustment for other known non-genetic risk factors (vascular risk factors, age and gender), rs16879248 in MTRR (5-methyltetra-hydrofolate-homocysteine methyltransferase reductase), rs11868708 in SHMT1 (serine hydroxymethyl-transferase 1) and rs11703570 in TCN2 (transcobalamin II), show suggestive association with ischemic stroke risk (P<0.05) (Table 2). This evidence concerns the gene SHMT1 and ischemic stroke.