As it was shown that 4-PBA can partially restore cellular trafficking (thus the function) of the ABCC7 cystic fibrosis mutant protein (ΔF508), we studied whether pre-treating mice with 4-PBA before HTVI could restore at least partial cellular trafficking of ABCC6 mutants that retained substantial transport activity. The gene discussed is ABCC6; the disease is cystic fibrosis.