In multiple logistic regression analysis using the presence of high Lp(a) concentrations as the dependent and age, sex, smoking, BMI, lipid concentrations, hypertension and diabetes as covariates we found that the polymorphism remained independently associated with high Lp(a) concentrations (odds ratio of the C-carriers 1.35, 95% CI 1.08 to 1.69, P = 0.009). The gene discussed is LPA; the disease is hypertensive disorder.