FOXP3 and neoplasm: In tumor tissue, most of FoxP3+ cells locate in the parenchymal region, where the FoxP3+ cells are close to liver tumor cells, while in non-tumor tissue, the majority of FoxP3+ cells aggregate in the mesenchymal region (parenchyma: mesenchyma, 7∶5 in tumor vs. 5∶22 in non-tumor, P<0.001; Figure 1e).